The Best Anti Inflammatory Medicine for Joint Pain: A Guide

When your knee or shoulder aches, do you really need a pill that affects your entire body? While oral medications are a common choice, they aren’t the only one. The debate between systemic relief from a pill and targeted relief from a topical is central to modern pain management. Finding the best anti inflammatory medicine for joint pain might mean combining approaches. A topical balm with cooling menthol and camphor can provide immediate, localized comfort for a sore joint, working alongside an oral medication that addresses deeper inflammation. Let’s explore the benefits of each so you can build a smarter, more effective plan.

Key Takeaways

Match Your Relief to Your Pain Type: Choose an anti-inflammatory like ibuprofen for swelling, acetaminophen for pain without swelling, or a topical with menthol and camphor for fast, targeted comfort right on the joint.
Build a Complete Pain Management Toolkit: A comprehensive plan often includes a combination of oral medications, targeted topical relief for flare-ups, and supportive lifestyle habits like an anti-inflammatory diet and gentle movement.
Recognize When to Consult a Professional: Over-the-counter options are for temporary relief. If your pain is severe, persistent, or worsens, it’s time to see a doctor to get a proper diagnosis and create a safe, long-term treatment plan.

What Are the Go-To Medications for Joint Pain?

When you’re standing in the pharmacy aisle staring at a wall of options, figuring out what to grab for your aching joints can feel overwhelming. Most of us just reach for whatever we’ve used before, but understanding how different medications work can help you make a more informed choice for your specific type of discomfort.

The most common medications for joint pain fall into a few key categories. Some work by reducing inflammation throughout your body, others focus on blocking pain signals in your brain, and some are applied directly to the skin for targeted relief. Each approach has its own set of benefits and is suited for different situations. Let’s break down the go-to options so you can feel more confident in your choice.

NSAIDs (Nonsteroidal Anti-Inflammatory Drugs)

NSAIDs are probably the most well-known option for joint pain, especially when swelling and inflammation are involved. This category includes over-the-counter medications like ibuprofen (Advil, Motrin) and naproxen (Aleve). They work by blocking the effects of enzymes that play a key role in producing substances called prostaglandins. These substances are major contributors to inflammation, so by reducing their production, NSAIDs help ease both swelling and pain right at the source. This makes them a popular first line of defense for everything from a tweaked knee to arthritis flare-ups.

Acetaminophen

Acetaminophen, best known by the brand name Tylenol, works differently than NSAIDs. While it’s effective for mild to moderate pain, it doesn’t have significant anti-inflammatory properties. Instead of targeting inflammation at the site of your sore joint, acetaminophen is thought to work in the central nervous system. It helps reduce fever and may block the transmission of pain signals within the brain, essentially turning down the volume on your discomfort. Because it doesn’t target inflammation, it’s often recommended for pain that isn’t accompanied by swelling, like osteoarthritis.

Prescription Options

For more severe or persistent joint pain, your doctor might recommend prescription-strength medications. These can include more potent NSAIDs that have long been a cornerstone of pharmacologic treatment for conditions like osteoarthritis. Other prescription options might include different classes of drugs designed to manage chronic pain or address specific underlying conditions. These medications require a doctor’s diagnosis and supervision to ensure they’re the right and safest choice for your health needs, as they often come with a higher risk of side effects.

Topical Solutions for Targeted Relief

If you prefer to target pain right where it hurts, topical solutions are an excellent option. These are creams, gels, balms, or patches that you apply directly to the skin over a sore joint. Some topicals contain NSAIDs, delivering the medication locally with a lower risk of the stomach issues that can sometimes accompany oral pills. According to Yale Medicine, this makes them a great choice for people who are sensitive to the gastrointestinal side effects of oral medications. Other topicals use ingredients like menthol and camphor to create a cooling or warming sensation that overrides pain signals, providing fast, localized comfort.

How Do Joint Pain Medications Actually Work?

Ever wonder what’s actually happening inside your body when you reach for a pain reliever? It’s not magic—it’s science. Different types of medications take completely different routes to quiet down joint pain. Some work like a firefighter, putting out the flames of inflammation right at the source. Others act more like a switchboard operator, rerouting pain signals before they can fully register in your brain.

Understanding these distinct approaches is the first step to figuring out which one might be the best fit for your body and your specific type of discomfort. Whether you’re dealing with a swollen knee after a run or a stiff neck from sitting at a desk, knowing how a medication functions helps you make a more informed choice. Let’s look at the mechanics behind three of the most common options: NSAIDs, acetaminophen, and topical solutions.

How NSAIDs Work: Targeting Inflammation

When your joints are swollen, tender, and achy, inflammation is usually the primary cause. NSAIDs (nonsteroidal anti-inflammatory drugs) are designed to tackle this problem head-on. Your body naturally produces compounds called prostaglandins, which are key drivers in the inflammatory process that causes pain and swelling. Research shows that NSAIDs work by blocking the enzymes that create these prostaglandins. Think of it as shutting down the factory that’s sending out pain and swelling signals. By reducing inflammation directly at the site of your discomfort, NSAIDs help ease the pain that comes along with it. This is the mechanism behind common medications like ibuprofen and naproxen.

How Acetaminophen Works: Muting Pain Signals

Acetaminophen takes a completely different path. Instead of targeting inflammation in your joints, it works primarily within your central nervous system—your brain and spinal cord. While its exact mechanism is still being studied, experts at Tufts School of Medicine explain that it appears to block the transmission of pain nerve impulses within the brain. In simple terms, it helps turn down the volume on pain signals before your brain can fully process them. This is why it’s effective for mild to moderate pain but doesn’t do much to reduce swelling. It’s the active ingredient in Tylenol and many other combination formulas for pain and colds.

How Topicals Work: Direct, Localized Relief

If you’re looking for relief right where it hurts, topical solutions are designed for exactly that. These creams, balms, and roll-ups are applied directly to the skin over a sore joint, delivering active ingredients locally. This means they can get to work without having to travel through your entire digestive system first. Many topicals use powerful plant-based ingredients like menthol and camphor to create a cooling or warming sensation that distracts your brain from the underlying pain. The Arthritis Foundation notes that this direct approach provides targeted relief right at the source, making it a great option for managing localized aches and stiffness.

Finding the Best Over-the-Counter Relief

Walking down the pharmacy aisle can feel overwhelming when you’re looking for something to ease your joint pain. With so many options, how do you know which one is right for you? The best over-the-counter (OTC) choice really comes down to your specific type of pain, your overall health, and what you feel most comfortable using. Generally, OTC relief falls into two main camps: oral medications you swallow, like pills, and topical treatments you apply directly to your skin.

Oral medications like ibuprofen and acetaminophen work systemically, meaning they affect your whole body after being digested and entering your bloodstream. This can be great for widespread or deep-seated pain. On the other hand, topicals like balms and creams deliver targeted relief right where you need it most, which is a huge plus for localized joint pain in areas like your knees, hands, or shoulders. Many people find that a combination of both offers the most comprehensive approach. Understanding how each one works is the first step in helping you choose your strength and find a routine that gets you back to feeling your best. It’s all about finding a solution that fits your lifestyle and provides consistent comfort.

Topical Balms with Menthol & Camphor

If you’re looking for fast, targeted relief, topical balms are a fantastic option. You apply them directly to the skin over the sore joint, and they get to work quickly without having to be processed through your digestive system. The key players in these formulas are often menthol and camphor. These ingredients create a cooling sensation that helps distract your brain from the pain signals. Think of it as a soothing, icy-hot effect that calms the area down.

Many modern formulas also include supportive plant-based ingredients. For instance, cannabinoids like CBD have been shown in some studies to work alongside menthol and camphor to provide added support. When you’re looking at different balms and roll-ups, check the label for these active ingredients to ensure you’re getting effective, terpene-powered relief.

Ibuprofen (Advil, Motrin)

Ibuprofen is one of the most common non-steroidal anti-inflammatory drugs (NSAIDs) you’ll find on the shelf. Its main job is to reduce both pain and inflammation. It works by blocking the production of enzymes in your body that create the substances responsible for swelling and pain. This makes it a go-to for inflammatory conditions like arthritis or for soreness after a tough workout. Because it tackles inflammation head-on, many people find it effective for joint pain that comes with noticeable swelling or stiffness. You can find more information on how these over the counter drugs work from health organizations.

Naproxen (Aleve)

Naproxen is another popular NSAID, similar to ibuprofen, but with one key difference: it lasts longer. A single dose of naproxen can provide relief for up to 12 hours, while ibuprofen typically lasts for about four to six. This makes it a more convenient option if you’re dealing with persistent, all-day pain and don’t want to keep taking pills. It’s also effective for managing pain from sprains, strains, and arthritis. Deciding on the best over-the-counter pain medication often comes down to balancing effectiveness with convenience, and naproxen’s long-lasting formula is a big draw for many.

Acetaminophen (Tylenol)

Unlike ibuprofen and naproxen, acetaminophen is not an NSAID. It’s an analgesic, which means it’s a pain reliever, but it doesn’t have significant anti-inflammatory properties. Acetaminophen works differently by changing the way your body senses pain and by cooling the body, which is why it’s also a fever reducer. It’s a great choice if your joint pain isn’t caused by inflammation or if you can’t take NSAIDs due to stomach issues or other health concerns. Research from institutions like Tufts School of Medicine helps explain how acetaminophen works to block those pain signals in the brain.

Understanding the Potential Risks and Side Effects

Grabbing a bottle of over-the-counter pain reliever is a common first step for managing joint pain, and for good reason—these medications can be effective. However, it’s important to remember that just because they’re readily available doesn’t mean they’re free of potential side effects, especially when used frequently or for long periods. Understanding these risks helps you make more informed decisions about your health and find a pain management plan that works for your body.

Many of these oral medications work throughout your entire system, not just on the painful joint. This systemic effect is what can lead to unintended consequences in other parts of your body. Being aware of the potential downsides of common oral medications allows you to weigh the benefits against the risks and discuss them with your doctor. This knowledge is key to creating a safe and sustainable approach to feeling your best.

Stomach and Digestive Issues

One of the most well-known side effects of NSAIDs like ibuprofen and naproxen is their impact on the stomach. These drugs work by blocking enzymes that cause inflammation, but they can also reduce the natural protection of your stomach lining. Over time, this can lead to irritation, heartburn, and even more serious issues like bleeding or ulcers. According to Arthritis Research Canada, this is a significant concern for those who rely on NSAIDs for daily relief. If you have a sensitive stomach or a history of ulcers, this is a critical factor to consider when choosing your pain reliever.

Kidney and Liver Health

Your kidneys and liver are your body’s filtration systems, and some pain medications can put extra strain on them. NSAIDs, if not used as directed, can potentially cause kidney damage over time. On the other hand, acetaminophen is processed by the liver, and taking too much can be harmful. It’s especially important to be careful with acetaminophen because it’s a common ingredient in many combination cold and flu medicines. As noted by Scripps Health, accidentally doubling up on doses is a real risk, so always check the labels of everything you’re taking.

Cardiovascular Concerns

The connection between certain pain relievers and heart health is something everyone should be aware of. With the exception of aspirin, many NSAIDs can increase the risk of heart attack and stroke. This risk is even greater for individuals who already have high blood pressure, heart disease, or other cardiovascular risk factors. If you have a history of heart issues, it’s a good idea to talk with your doctor before regularly using NSAIDs like ibuprofen or naproxen. Your heart health should always be a top priority when choosing a pain management strategy.

Drug Interactions and Age-Related Risks

Over-the-counter medications aren’t taken in a vacuum—they can interact with prescription drugs you may be taking for other conditions. These interactions can either make your other medications less effective or increase the risk of side effects. It’s always a good practice to review all your medications with your doctor or pharmacist. Additionally, our bodies change as we age, and so does our tolerance for certain drugs. For example, naproxen is often not recommended for people over 65 due to a higher risk of side effects like stomach bleeding.

Natural Remedies to Support Your Treatment Plan

While over-the-counter and prescription medications are effective tools, they aren’t the only options for managing joint pain. Many people find that incorporating natural remedies and lifestyle adjustments into their routine provides an extra layer of support. These strategies can work alongside your primary treatment plan to help you feel your best. From powerful plant-based ingredients to simple dietary changes, these natural approaches can make a real difference in your daily comfort and mobility.

As always, it’s a great idea to chat with your doctor before adding new supplements or remedies to your regimen, especially if you’re already taking other medications. They can help you create a well-rounded plan that’s safe and effective for your specific needs.

The Cooling Power of Menthol and Camphor

If you’re looking for immediate, localized relief, topical products with menthol and camphor are a fantastic option. These ingredients work by creating a cooling sensation on your skin. This sensation acts as a counterirritant, essentially distracting your brain from the deeper feelings of pain in your muscles or joints. Think of it as creating a soothing signal that overrides the discomfort. You can find these powerful ingredients in easy-to-use balms, roll-ups, and lotions that you apply directly to the sore area, giving you targeted relief right where you need it most.

Fish Oil and Omega-3s

You’ve probably heard about the benefits of omega-3 fatty acids for heart and brain health, but they’re also great for your joints. Fish oil is packed with these healthy fats, which are known to have anti-inflammatory properties. Some research indicates that regularly taking fish oil supplements can help reduce joint stiffness, tenderness, and swelling. It’s a simple dietary addition that can support your body’s natural ability to manage inflammation from the inside out, making it a popular choice for those with chronic joint discomfort.

Turmeric and Curcumin

That bright yellow spice in your cabinet does more than just flavor your food. Turmeric contains an active compound called curcumin, which is a potent anti-inflammatory. Studies have shown that curcumin can be surprisingly effective at easing pain, with some research suggesting it works as well as ibuprofen for people with knee osteoarthritis. You can add more turmeric to your cooking or consider taking a curcumin supplement to get a more concentrated dose. It’s a natural way to help calm inflammation and support overall joint health.

Glucosamine and SAM-e

Walking down the supplement aisle, you’ll likely see glucosamine and chondroitin, two popular options for joint health. While the research on their effectiveness is mixed, many people feel they provide some relief. Another compound, SAM-e (S-adenosylmethionine), has also shown significant promise. It’s a substance your body produces naturally that plays a role in pain and inflammation. Some studies suggest that taking a SAM-e supplement can help protect cartilage and may be as effective as some NSAIDs for osteoarthritis pain.

Combining Natural and Traditional Methods

Finding the perfect pain management strategy is often a process of trial and error. There’s no single solution that works for everyone, and what helps you today might need adjusting tomorrow. The most effective approach is often a combination of methods. Pairing a topical analgesic with an anti-inflammatory diet or using a daily supplement alongside gentle exercise can create a more comprehensive plan. The key is to listen to your body, stay patient, and work with your healthcare provider to find the unique blend of treatment options that keeps you moving comfortably.

How to Choose the Right Treatment for You

Finding the right pain relief isn’t about discovering one magic bullet; it’s about creating a personalized toolkit that fits your body, your pain, and your life. What works wonders for a friend might not be the best fit for you, and that’s completely normal. The goal is to find a sustainable approach that helps you feel better without causing unwanted side effects or disrupting your routine. This means taking a moment to understand your specific needs before you head to the pharmacy or shop online.

Thinking through a few key factors can help you make a more informed and confident choice. By considering the nature of your pain, your health history, and your daily habits, you can build a pain management plan that feels right. Let’s walk through the steps to pinpoint the best options for you.

First, Assess Your Pain

Before you can treat your pain effectively, it helps to understand it. Is it a sharp, sudden ache from a workout, or a dull, persistent throb that’s been around for a while? Does it get worse at certain times of day? Does it keep you from sleeping or enjoying your favorite activities? According to the Mayo Clinic, effective pain management should address the physical, mental, and emotional aspects of your health. Taking stock of how your pain truly affects you will guide you toward the most appropriate solution, whether it’s a fast-acting topical for immediate relief or a daily medication for ongoing management.

Consider Your Personal Health History

Your personal health history is a critical piece of the puzzle. Certain health conditions, like high blood pressure, kidney problems, or stomach sensitivity, can influence which medications are safe for you. For example, some research suggests that acetaminophen may be a better choice than NSAIDs for people with high blood pressure. It’s always a good idea to talk with your doctor or pharmacist before starting a new treatment, especially if you take other medications. They can help you understand potential interactions and choose an option that won’t interfere with your overall health.

Pairing Topical and Oral Options

You don’t always have to choose between a pill and a balm. In fact, combining them is often a powerful strategy. While oral anti-inflammatories work systemically throughout your body, topical solutions deliver targeted relief directly to the source of your discomfort. The Arthritis Foundation notes that creams and balms containing ingredients like menthol and camphor can be very effective. Using a topical like one of our Roll-Ups can provide immediate cooling comfort for a sore joint, complementing the work of an oral medication that’s addressing inflammation from the inside out.

Weighing Cost and Accessibility

Practicality matters. The most effective treatment is one you can access easily and use consistently. Over-the-counter options are generally affordable and readily available, but it’s still wise to consider your budget. Think about how often you’ll need to use a product. For daily aches, buying a larger Jar might be more cost-effective in the long run, while having a smaller travel-size version on hand ensures you’re never without support. Exploring different options, like our discounted Bundles, can also help make your pain management plan more affordable and sustainable.

Lifestyle Habits That Help Ease Joint Pain

Finding the right medication is a great step, but it’s only one part of an effective pain management strategy. The small choices you make every day can have a huge impact on how your joints feel. Think of your body like a high-performance machine—it runs best when you give it the right fuel, proper maintenance, and adequate rest. Integrating healthy habits doesn’t have to be a total life overhaul. Instead, focus on making small, sustainable changes that work together to support your joints, reduce discomfort, and complement your treatment plan.

When you pair these lifestyle adjustments with effective topical solutions, you create a powerful, two-pronged approach. While a topical balm works from the outside to soothe discomfort with ingredients like menthol and camphor, these daily habits work from the inside to build a stronger, more resilient foundation for your body. It’s about creating an environment where your joints can thrive. From the food you eat to the way you move, these practices can help you feel more in control of your joint health and overall well-being.

Eating an Anti-Inflammatory Diet

What you eat can directly influence inflammation levels in your body. An anti-inflammatory diet isn’t about restriction; it’s about choosing foods that help your body fight back against inflammation. Focus on incorporating more fruits, vegetables, nuts, beans, and fatty fish like salmon into your meals. These foods are packed with antioxidants and nutrients that support joint health. At the same time, try to limit processed foods, sugary drinks, and unhealthy fats, which can contribute to inflammation. Simple swaps, like choosing olive oil over butter or snacking on berries instead of cookies, can make a real difference over time.

Gentle, Low-Impact Exercise

When your joints hurt, exercise might be the last thing on your mind. However, the right kind of movement is one of the best things you can do for joint pain. Gentle, low-impact activities like walking, swimming, cycling, or yoga can help reduce stiffness and strengthen the muscles that support your joints. Regular gentle exercise also encourages your body to release endorphins, which are natural pain relievers. The key is to start slow and listen to your body. Even 15-20 minutes a day can improve your mobility and decrease discomfort without putting extra strain on sensitive joints.

Using Heat and Cold Therapy

Applying heat and cold are simple yet effective ways to manage joint pain. A good rule of thumb is to use heat for chronic stiffness and aches, and cold for acute pain and inflammation. A warm compress or a warm bath can help relax muscles and soothe stiff joints, making it a great way to start your day. On the other hand, a cold pack can help numb sharp pain and reduce swelling after an activity. Many topical analgesics, like our Roll-Ups, use menthol and camphor to create a cooling sensation that provides similar, targeted relief right where you need it.

Prioritizing Stress Management and Sleep

Your mental and emotional well-being are directly linked to your physical health. High stress levels can cause your muscles to tense up, which can worsen joint pain. Likewise, a lack of quality sleep robs your body of the time it needs to repair itself. Managing stress through practices like deep breathing, meditation, or spending time in nature can have a calming effect on your entire system. Creating a relaxing bedtime routine to ensure you get enough restorative sleep is just as important. When your mind is at ease and your body is well-rested, you’re better equipped to handle pain.

When Is It Time to See a Doctor?

Taking control of your joint pain often starts at home with trusted over-the-counter (OTC) options and effective topical solutions. For many everyday aches and minor strains, this approach is all you need to feel better. But self-care also means knowing when to call in a professional. While topical balms and oral medications can provide significant relief, they aren’t a substitute for a proper diagnosis from a healthcare provider, especially when pain is severe, persistent, or accompanied by other concerning symptoms.

Think of your doctor as your partner in wellness. They can help you understand the root cause of your joint pain—whether it’s arthritis, an injury, or something else entirely—and create a safe, effective treatment plan tailored to you. Ignoring persistent pain or pushing through serious symptoms can sometimes make things worse in the long run. Learning to recognize the signs that your body needs more support is a crucial step in managing your health proactively and getting back to doing what you love, pain-free.

Red Flags: When to Call Your Doctor

Your body is great at sending signals when something isn’t right, and it’s important to listen. While a dull ache after a long day might be normal, certain symptoms are red flags that warrant a call to your doctor. According to Arthritis Research Canada, getting proper medical help early is key for your long-term health.

Schedule an appointment if you experience:

Pain accompanied by fever or unexplained weight loss
Sudden, severe, or debilitating pain
Joints that are red, hot to the touch, or significantly swollen
Pain that affects multiple joints at once
Inability to move a joint or bear weight on it

These signs could point to an underlying condition that requires a specific diagnosis and treatment plan.

When OTC Options Aren’t Cutting It

You’ve been consistent with your routine—maybe you’re using a topical balm, taking ibuprofen, and resting—but the pain just isn’t letting up. Or worse, it’s starting to interfere with your daily life. This is a clear sign that it’s time to seek professional medical advice.

If your go-to pain medicine isn’t working or your symptoms are getting worse, Scripps Health advises seeing your doctor. An OTC remedy can mask pain, but it can’t diagnose the cause. A doctor can perform an examination, run tests if needed, and provide a diagnosis that explains why your current approach isn’t providing the relief you need. From there, they can recommend a more effective strategy.

Safely Managing Long-Term Treatment

For those dealing with chronic conditions like arthritis, managing joint pain is an ongoing process, not a one-time fix. This is where building a strong, collaborative relationship with your doctor becomes essential. Long-term use of any medication, including OTC drugs, comes with potential risks that need to be monitored by a professional.

According to the Mayo Clinic, it’s crucial to work closely with your healthcare provider to find the best long-term plan for you. They can help you weigh the benefits and risks of different medications, adjust dosages as needed, and integrate other therapies like physical therapy or lifestyle changes. Regular check-ins ensure your treatment remains both safe and effective over time.

Building Your Personal Pain Management Plan

The most successful approach to managing joint pain is one that’s created just for you. A personalized pain management plan goes beyond just taking a pill or applying a cream; it’s a comprehensive strategy developed with your doctor that addresses your specific needs, health history, and lifestyle.

Your plan should be a living document that you and your doctor review and adjust as your symptoms change. It might include a combination of treatments: targeted topical relief for flare-ups, a specific oral medication, gentle exercises, dietary adjustments, and stress management techniques. By staying engaged and maintaining open communication with your doctor, you can build a sustainable plan that helps you manage your pain effectively and live your life more comfortably.

Frequently Asked Questions

What’s the real difference between taking a pill like ibuprofen and using a topical balm? Think of it as the difference between a systemic and a targeted approach. When you swallow a pill, it travels through your digestive system and into your bloodstream to work throughout your entire body. A topical balm, on the other hand, delivers active ingredients like menthol and camphor directly to the specific area where you apply it. This localized method allows you to get relief right at the source of your discomfort without the medication having to affect your whole system.

Can I use a topical pain reliever and take an oral medication at the same time? Yes, many people find this combination to be a very effective strategy. Using both creates a comprehensive approach to managing discomfort. The oral medication can work from the inside to address underlying inflammation, while a topical balm provides immediate, cooling relief on the outside. This pairing can be especially helpful for flare-ups, but it’s always a good idea to chat with your doctor or pharmacist to make sure the combination is right for your specific health needs.

I’m worried about the side effects of oral pain relievers. Are topicals a safer option for long-term use? Topical solutions are often a great choice for people who are concerned about the potential side effects of oral medications, particularly stomach irritation. Because the active ingredients are absorbed through the skin at the site of application, they are less likely to cause the systemic issues that can sometimes come with long-term pill use. While this makes them a preferred option for many, you should always discuss any long-term pain management plan with your doctor to ensure it’s the safest and most effective route for you.

My joint pain isn’t severe, but it’s annoying. When should I actually see a doctor instead of just managing it myself? It’s smart to see a doctor if your pain persists for more than a week or two despite using over-the-counter options, or if it starts getting worse. You should also make an appointment if the pain is accompanied by other symptoms like significant swelling, redness, fever, or if it starts interfering with your sleep or daily activities. Self-care is important, but a professional diagnosis is the best way to understand the root cause and get on the right treatment path.

With so many options, how do I choose between ibuprofen, naproxen, and acetaminophen for my specific pain? A simple way to decide is to consider whether your pain involves swelling. Ibuprofen and naproxen are anti-inflammatories, making them a good choice for pain accompanied by swelling, like after an injury or during an arthritis flare-up; the main difference is that naproxen lasts longer. Acetaminophen is a pain reliever but doesn’t target inflammation, so it’s better suited for aches and pains without noticeable swelling, such as from osteoarthritis.

How to Choose the Best Anti Inflammatory Medicine for Joint Pain